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Updated: May 16, 2026
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Prospective longitudinal study of corneal collagen cross-linking in progressive keratoconus
Deepa Viswanathan1, John Males
1Australian School of Advanced Medicine, Macquarie University, Sydney, New South Wales, Australia. deepa.viswanathan@students.mq.edu.au
Background:
Collagen cross-linking has been reported to be effective in treating progressive keratoconus, and this study aims to evaluate the long-term efficacy of this procedure.
Design:
Prospective longitudinal interventional study of patients with progressive keratoconus who underwent cross-linking in a tertiary referral hospital.
Participants:
Thirty-five patients (51 eyes) who underwent cross-linking with a mean follow-up of 14.38 ± 9.36 months (range 6-48) were compared with a control group of 25 fellow eyes that did not undergo the procedure.
Methods:
Cross-linking was performed using 0.1% riboflavin (in 20% dextran T500) and ultraviolet A irradiation (370 nm, 3 mW/cm(2) , 30 min).
Main Outcome Measures:
Maximum keratometry in dioptres, logMAR best spectacle-corrected visual acuity, cylindrical power, manifest refraction spherical equivalent and central corneal thickness.
Results:
Analysis of the treated group demonstrated a significant flattening of maximum keratometry by 0.96 ± 2.33 dioptres (P = 0.005) and a significant improvement in visual acuity by 0.05 ± 0.13 logMAR (P = 0.04). In the control group, maximum keratometry increased significantly by 0.43 ± 0.85 dioptres (P = 0.05), and visual acuity decreased by mean 0.05 ± 0.14 (P = 0.2). No statistical differences were noted regarding cylindrical power, spherical equivalent or corneal thickness in both groups.
Conclusions:
Results indicate that corneal collagen cross-linking using riboflavin and ultraviolet A is effective as a therapeutic option in cases of progressive keratoconus by reducing the corneal curvature and by improving the visual acuity in these patients.
