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Related Experiment Videos

Nifedipine for intractable hiccups.

D C Lipps1, B Jabbari, M H Mitchell

  • 1Neurology Service, Walter Reed Army Medical Center, Washington, DC 20307-5001.

Neurology
|March 1, 1990
PubMed
Summary
This summary is machine-generated.

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Nifedipine, a calcium channel blocker, effectively treated intractable hiccups in some patients. Four out of seven patients experienced complete relief, with one showing improvement, highlighting its potential therapeutic role.

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Intractable hiccups present a significant clinical challenge.
  • Limited effective treatment options exist for persistent hiccups.

Purpose of the Study:

  • To evaluate the efficacy of nifedipine, a calcium channel blocker, in managing intractable hiccups.

Main Methods:

  • Seven patients with intractable hiccups were administered daily doses of nifedipine (30-60 mg).
  • Treatment outcomes including complete resolution and partial improvement were monitored.

Main Results:

  • Nifedipine successfully stopped hiccups in 4 out of 7 patients.
  • An additional patient experienced improvement in hiccup symptoms.
  • Hiccups recurred within 24 hours in 2 patients upon drug discontinuation.

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Conclusions:

  • Nifedipine demonstrates potential as an effective treatment for some cases of intractable hiccups.
  • The calcium channel blocker may offer a viable therapeutic option for refractory hiccup cases.