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Role of fetuin-A in atherosclerosis associated with diabetic patients
Monika Singh1, Pramod Kumar Sharma, Vipin Kumar Garg
1Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut Department of Pharmaceutical Technology, Divya Jyoti College of Pharmacy, Modinagar, Uttar Pradesh, India. singhmonika878@gmail.com
Objectives:
Fetuin-A is a circulating glycoprotein, formed in the liver. It regulates bone remodelling and calcium metabolism. Fetuin-A has adipogenic properties, so fat accumulation in the liver may be associated with higher levels of fetuin-A. Fetuin-A is an inhibitor of the phosphorylation of the insulin receptor tyrosine kinase.
Key Findings:
High concentrations of fetuin-A in humans causes insulin resistance. Insulin sensitivity is also found to be increased in fetuin-A knockout mice. Fetuin-A has been shown to cause insulin resistivity in type-2 diabetes mellitus and worsens the pro-atherogenic milieu.
Summary:
Fetuin-A should be considered as a hepatic bio-marker. Vascular diseases like atherosclerosis are major causes of disability in patients with diabetes mellitus.
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