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Related Experiment Video

Updated: May 16, 2026

Decellularization-Based Quantification of Skeletal Muscle Fatty Infiltration

Decellularization-Based Quantification of Skeletal Muscle Fatty Infiltration

Published on: June 9, 2023

Body fat predicts an increase and limb muscle strength predicts a decrease in leptin in older adults over 2·6 years.

Benny Antony¹, Graeme Jones, Oliver Stannus

¹Menzies Research Institute, University of Tasmania, Hobart, Australia.

Clinical Endocrinology

|November 14, 2012

Summary

Leg muscle strength negatively predicts leptin levels in older adults, suggesting strength training may combat obesity-related health issues like hyperleptinaemia.

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Fiber Type and Subcellular-Specific Analysis of Lipid Droplet Content in Skeletal Muscle

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Published on: June 8, 2022

Area of Science:

Gerontology
Metabolic Health
Obesity Research

Background:

Obesity is linked to hyperleptinaemia, increasing risks for diabetes, hypertension, and heart disease.
Leptin, a hormone regulating appetite and metabolism, is often elevated in obese individuals.

Purpose of the Study:

To investigate if body fat and muscle measures predict changes in leptin levels over 2.6 years in older adults.
To understand the relationship between body composition, muscle strength, and leptin dynamics in aging populations.

Main Methods:

Serum leptin levels, height, weight (BMI), body composition (DXA), and muscle strength (dynamometry) were measured in 190 adults aged 50-79.
Longitudinal analysis tracked changes in leptin over a 2.6-year period.
Multivariable and gender-specific analyses were conducted.

Main Results:

Increased body fat and trunk fat positively correlated with leptin levels.
Leg muscle strength showed a negative association with both baseline and follow-up leptin.
Lean mass was negatively associated with baseline leptin.

Conclusions:

Leg muscle strength is a significant negative predictor of leptin levels in older adults.
Maintaining or enhancing muscle strength may offer a protective effect against hyperleptinaemia.
Body fat and trunk fat are positively associated with leptin, reinforcing the link between adiposity and elevated leptin.