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Related Concept Videos

Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...

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Related Experiment Video

Updated: May 16, 2026

Noninvasive, In-pen Approach Test for Laboratory-housed Pigs
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Published on: June 5, 2019

Brain gene expression differences are associated with abnormal tail biting behavior in pigs.

E Brunberg1, P Jensen, A Isaksson

  • 1Department of Animal Environment and Health, Swedish University of Agricultural Sciences, Uppsala, Sweden. emma.brunberg@bioforsk.no

Genes, Brain, and Behavior
|November 14, 2012
PubMed
Summary
This summary is machine-generated.

Gene expression in pigs reveals differences linked to tail biting behavior. Specific genes in neutral pigs may explain their lack of involvement in this welfare issue.

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Related Experiment Videos

Last Updated: May 16, 2026

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Use of a Piglet Model for the Study of Anesthetic-induced Developmental Neurotoxicity (AIDN): A Translational Neuroscience Approach

Published on: June 11, 2017

Area of Science:

  • Animal behavior genetics
  • Livestock welfare research

Background:

  • Tail biting is an abnormal, injurious behavior causing significant welfare problems in pig production.
  • Understanding the genetic and motivational factors behind tail biting is crucial for improving animal welfare.

Purpose of the Study:

  • To investigate gene expression differences in the hypothalamus and prefrontal cortex of pigs exhibiting tail biting behavior.
  • To identify potential biological mechanisms underlying tail biting by comparing gene expression in tail biters, receivers, and neutral pigs.

Main Methods:

  • Utilized Affymetrix microarrays to analyze gene expression profiles.
  • Compared gene expression in the hypothalamus and prefrontal cortex across three groups: tail biters, receiver pigs, and neutral pigs.

Main Results:

  • Significant differences in gene expression were observed in both the hypothalamus and prefrontal cortex between groups.
  • 19 genes showed distinct expression patterns in neutral pigs compared to both performers and receivers, suggesting a role in preventing involvement in tail biting.
  • Identified genes associated with production traits (PDK4), sociality (GTF2I), and novelty seeking (EGF) in neutral pigs.

Conclusions:

  • Gene expression patterns in the hypothalamus and prefrontal cortex are associated with tail biting behavior in pigs.
  • Specific genes in neutral pigs may confer resistance to engaging in or receiving tail biting.
  • Findings support hypotheses linking tail biting to production traits and explorative behaviors.