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[Detection of micro-embolic signals: a review of the literature]
C Boulon1, J-M Baud, G Kercret
1Service de Médecine Vasculaire, Hôpital St-André, 1, rue Jean-Burguet, 33075 Bordeaux, France. carine.boulon@chu-bordeaux.fr
Background:
The detection of micro-embolic signals (MES), by transcranial Doppler sonography might be useful for risk stratification in patients with symptomatic and asymptomatic carotid or cerebral artery stenosis, dissections, aortic atheroma, interventional procedures, and right to left cardiac shunts.
Aim:
Review of the technique and clinical situations of MES detection.
Methods:
PubMed search from 1990 to 2012.
Results:
MES were found in 0,19, 48% versus 0,3, and 12% of patients with symptomatic and asymptomatic inferior than 30, 30 to 69, and 70 to 99% carotid stenosis, respectively. MES were related to the risk of recurrent stroke or transient ischemic attack (TIA). In the ACES study, the absolute annual risk of stroke or TIA after 2 years was 7% with vs 3% without MES. In patients with intracranial stenosis, the risk of stroke recurrence was 48% with vs 7% without MES at 13.6 months follow-up. MES were reported in 25% of the symptomatic versus none of the asymptomatic patients with intracranial stenosis.
Conclusion:
Detection of MES is feasible and reproducible for multicenter studies, using rigourous methodology and long lasting recordings. It may contribute to risk stratification, especially in patients with extra- or intracranial stenosis.
