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Updated: May 16, 2026
06:59
A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection
Published on: February 2, 2022
PARVG gene polymorphism and operational renal allograft tolerance
R Danger1, E Thervet, M-L Grisoni
1INSERM U643, and Institut de Transplantation Urologie Néphrologie du Centre Hospitalier Universitaire Hôtel Dieu, Nantes, France.
Transplantation Proceedings
|November 14, 2012
Summary
Genetic variations in kidney transplant recipients may influence gene expression related to operational tolerance. Specific single nucleotide polymorphisms (SNPs) in the PARVG gene were linked to altered gene expression and patient status, suggesting new regulatory pathways.
Area of Science:
- Immunology
- Genetics
- Transplantation
Background:
- A 49-gene blood transcriptional profile distinguishes operationally tolerant (TOL) kidney recipients from others.
- The influence of genetic polymorphisms on this profile and clinical status is unknown.
Purpose of the Study:
- Investigate if genetic polymorphisms affect the 49-gene expression profile.
- Determine if single nucleotide polymorphisms (SNPs) correlate with kidney transplant recipient clinical status.
Main Methods:
- Genotyped 1152 tag SNPs in 164 kidney transplant recipients (TOL, stable, chronic rejection) and healthy volunteers.
- Analyzed gene expression and clinical status in relation to SNPs using Illumina assay.
Main Results:
- Two SNPs (rs139144, rs5764592) in the PARVG gene explained 20% of its expression variability.
- The rs139144GG genotype correlated with lower PARVG expression and was more frequent in TOL patients (60%) versus chronic rejection/stable (CR&STA) patients (28%).
Conclusions:
- Preliminary findings suggest PARVG SNPs influence gene expression and may be associated with kidney transplant operational tolerance.
- Further validation in larger cohorts is needed to confirm these results and explore regulatory pathways.
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