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Frequency of HBsAg positivity: a laboratory data analysis
Farhan Essa Abdullah1, Akhtar Amin Memon, Ammara Mushtaq
1Department of Pathology, Dow Medical College, Dow University of Health Sciences, Karachi. drfarhanessa@essalab.com
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|November 14, 2012
Summary
Hepatitis B virus (HBV) infection, indicated by Hepatitis B surface antigen (HBsAg) seropositivity, is increasing in Pakistan. The study found a 6.4% HBsAg rate, predominantly in young adults and males.
Area of Science:
- Hepatology
- Infectious Diseases
- Public Health
Background:
- Hepatitis B virus (HBV) infection remains a significant global health concern.
- Understanding the seroprevalence of Hepatitis B surface antigen (HBsAg) is crucial for targeted public health interventions.
- Previous data on HBsAg frequency in Pakistan indicated a need for updated epidemiological insights.
Purpose of the Study:
- To determine the current frequency of HBsAg seropositivity in a Pakistani laboratory setting.
- To analyze HBsAg prevalence based on demographic factors such as age and sex.
- To assess trends in HBsAg seropositivity within the studied population.
Main Methods:
- A retrospective study was conducted from September 2009 to November 2010.
- 8,648 blood samples were screened for HBsAg using the BioRad EVOLIS Enzyme Immunoassay (EIA) method.
- Physician questionnaires were also reviewed to supplement laboratory data.
Main Results:
- A total of 551 individuals (6.4%) tested positive for HBsAg.
- The highest seropositivity rate was observed in the 16-29 year age group (43.9%).
- Males (65.3%) showed a higher seropositivity rate compared to females (34.6%).
Conclusions:
- The HBsAg seropositivity rate in the studied Pakistani population has shown a concerning increase.
- Hepatitis B infection is more prevalent in the sexually active age group.
- Males are disproportionately affected by HBsAg seropositivity.
