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Prevalence of peripheral arterial disease in hemodialysis patients

Mosadegh Jabbari1, Mitra Kazemi Jahromi, Nasime Bahar

  • 1Rasul Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Iranian Journal of Kidney Diseases
|November 14, 2012
PubMed

Insights

Peripheral arterial disease (PAD) affects 10% of hemodialysis patients, linked to higher LDL and cholesterol. Ankle-brachial index (ABI) showed no association with carotid artery intima-media thickness (CIMT) or interventricular septum (IVS) thickness.

Area of Science:

  • Nephrology
  • Cardiology
  • Vascular Medicine

Background:

  • Subclinical atherosclerosis is a concern in hemodialysis patients.
  • Noninvasive markers like ankle-brachial index (ABI), carotid artery intima-media thickness (CIMT), and interventricular septum (IVS) thickness are used for prediction.
  • This study investigated peripheral arterial disease (PAD) prevalence and its relation to these markers and blood parameters in hemodialysis patients.

Purpose of the Study:

  • To determine the prevalence of peripheral arterial disease (PAD) in hemodialysis patients.
  • To assess correlations between ABI, CIMT, IVS thickness, and various blood parameters.
  • To identify risk factors associated with PAD in this population.

Main Methods:

  • Fifty hemodialysis patients were assessed for ABI, CIMT, and IVS thickness.
  • Blood parameters including calcium, lipids (cholesterol, LDL, HDL, triglycerides), creatinine, albumin, and erythrocyte sedimentation rate were measured.
  • Statistical analysis was performed to find correlations and significant differences.

Main Results:

  • 10% of patients exhibited a reduced ABI (< 0.9), indicating PAD.
  • Patients with normal ABI had significantly higher serum levels of calcium, cholesterol, LDL, HDL, and triglycerides compared to those with reduced ABI.
  • A negative correlation was observed between ABI and serum LDL cholesterol (LDLC) and triglyceride levels.
  • CIMT and IVS thickness did not show a significant association with ABI.

Conclusions:

  • The prevalence of PAD in patients with chronic renal failure (CRF) undergoing hemodialysis is 10%.
  • PAD in this cohort is associated with classical atherosclerosis risk factors, notably elevated LDL and cholesterol levels.
  • CIMT and IVS thickness were not found to be associated with ABI in this study population.
Abstract

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