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Updated: May 16, 2026

Novel Sequence Discovery by Subtractive Genomics
Published on: January 25, 2019
A novel statistical measure for sequence comparison on the basis of k-word counts
1School of Mathematical Sciences, Dalian University of Technology, Dalian, Liaoning 116024, PR China. cinema@lnnu.edu.cn
Abstract:
Numerous efficient methods based on word counts for sequence analysis have been proposed to characterize DNA sequences to help in comparison, retrieval from the databases and reconstructing evolutionary relations. However, most of them seem unrelated to any intrinsic characteristics of DNA. In this paper, we proposed a novel statistical measure for sequence comparison on the basis of k-word counts. This new measure removed the influence of sequences' lengths and uncovered bulk property of DNA sequences. The proposed measure was tested by similarity search and phylogenetic analysis. The experimental assessment demonstrated that our similarity measure was efficient.
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