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Anterior segment evaluation of infants with retinopathy of prematurity
M E Hartnett1, M M Gilbert, T M Richardson
1Eye Research Institute, Massachusetts Eye and Ear Infirmary, Boston, MA.
Insights
Glaucoma in retinopathy of prematurity (ROP) involves anterior segment abnormalities. This study found structural changes in ROP infants, suggesting developmental origins for these ocular conditions.
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Developmental Biology
Background:
- Glaucoma is a potential complication of retinopathy of prematurity (ROP).
- Understanding anterior segment changes is crucial for ROP glaucoma mechanisms.
- Previous research has not fully detailed the specific anterior segment structures affected in ROP.
Abstract:
To understand the mechanisms of glaucoma in retinopathy of prematurity (ROP), anterior segment evaluation is essential. The authors prospectively examined the anterior segment of 27 eyes of 17 premature infants with stages IV and V ROP. Twenty-six eyes received no previous surgery or treatment. Schiøtz and applanation tonometry were performed. Structural evaluation of each anterior segment was conducted by biomicroscopy and Koeppe gonioscopy. In the 26 eyes, angle closure of greater than 180 degrees was noted in 3 (12%). The authors noted prominent Schwalbe's line in 4 eyes (15%), high iris convexity in 15 (58%), hypopigmentation of the iris root in 19 (73%), translucent matrix in the angles ("Barkan's-type" membrane) in 18 (69%), posterior synechiae in 16 (62%), visible iris or angle vessels in 12 (46%), and pigment clumping in the angle recess in 12 (46%). This study identified structural abnormalities in the anterior segment of ROP infants, including pathologic changes and anatomic features that could have a developmental origin.