Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The barrier function in extracapsular cataract surgery.

R T Smith1, C J Campbell, C J Koester

  • 1Edward S. Harkness Eye Institute, Columbia Presbyterian Medical Center, New York.

Ophthalmology
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pesticides detected in two urban areas have implications for local butterfly conservation.

Environmental toxicology and chemistry·2025
Same author

North of England Women's Diet and ActivitY - After Breast Cancer (NEWDAY-ABC) intervention in women diagnosed with early oestrogen-positive, HER2-negative breast cancer: a randomised controlled feasibility study.

Pilot and feasibility studies·2025
Same author

Ballet and how it can improve neuromuscular function with age.

Journal of neurophysiology·2025
Same author

Ethical Stakes for Past, Present, and Prospective Tuberculosis Isolate Research Towards a Multicultural Data Sovereignty Model for Isolate Samples in Research.

Journal of bioethical inquiry·2024
Same author

Enhancing emission control and analyzing the performance and combustion attributes of vehicular engines with spirulina microalgae diesel Ce<sub>2</sub>O<sub>3</sub> nanoparticles blends.

Environmental research·2023
Same author

Daytime Sleepiness Is Associated with Lower Cognitive Scores: The Look AHEAD Study.

JAR life·2023
Same journal

Metastasis of Nasopharyngeal Squamous Cell Carcinoma to the Angle.

Ophthalmology·2026
Same journal

Endocrine Mucin-Producing Sweat Gland Carcinoma of Eyelid.

Ophthalmology·2026
Same journal

Multimodal Imaging of Optic Nerve Invasion in Unilateral Retinoblastoma.

Ophthalmology·2026
Same journal

Avacincaptad Pegol Slows Progressive Ellipsoid Zone Degradation/Loss in Eyes With Geographic Atrophy.

Ophthalmology·2026
Same journal

Access to Intravitreal Anti-VEGF Drugs in Persons with Medicare Advantage Compared with Medicare Fee-For-Service.

Ophthalmology·2026
Same journal

Re: Dones et al.: Emergency department use of ocular point-of-care ultrasound and its utility in diagnosis at a tertiary academic medical center (Ophthalmology. 2026;133:720-727).

Ophthalmology·2026
See all related articles

Extracapsular cataract extraction (ECCE) with intact capsule shows less fluorescein penetration into the anterior vitreous compared to intracapsular cataract extraction (ICCE). This suggests ECCE may create a barrier to posterior molecule movement in the eye.

Area of Science:

  • Ophthalmology
  • Ocular Physiology
  • Pharmacokinetics

Background:

  • Cataract surgery techniques, extracapsular cataract extraction (ECCE) and intracapsular cataract extraction (ICCE), differ in their impact on ocular barriers.
  • Understanding the permeability of the blood-aqueous barrier after different cataract surgeries is crucial for predicting drug delivery and inflammatory responses.

Purpose of the Study:

  • To compare the distribution of fluorescein between the anterior chamber and anterior vitreous in patients who underwent ECCE versus ICCE.
  • To assess the influence of surgical technique on the permeability of ocular barriers to systemically administered molecules.

Main Methods:

  • Oral administration of fluorescein to two groups of patients: ECCE with posterior chamber intraocular lens (PC IOL) and ICCE with anterior chamber intraocular lens (AC IOL).

Related Experiment Videos

  • Measurement of fluorescein concentrations using fluorophotometry.
  • Calculation of fluorescein penetration ratios to quantify movement into the anterior vitreous.

    • Main Results:

    • Significantly lower fluorescein penetration ratios were observed in the ECCE group (2.03 x 10(-3) min-1) compared to the ICCE group (5.99 x 10(-3) min-1).
    • This indicates a reduced passage of fluorescein from the anterior chamber to the anterior vitreous in ECCE patients.

    Conclusions:

    • Extracapsular cataract extraction with an intact capsule creates a more significant barrier to the posterior movement of molecules compared to intracapsular cataract extraction.
    • This finding has implications for understanding the transport of other molecules, such as prostaglandins, into the posterior segment of the eye after cataract surgery.