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Related Concept Videos

Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
Knee Joint01:23

Knee Joint

The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris group...

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Related Experiment Video

Updated: May 16, 2026

The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve
09:51

The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve

Published on: September 7, 2022

Assessing function in patients undergoing joint replacement: a study protocol for a cohort study.

Vikki Wylde1, Ashley W Blom, Stijn Bolink

  • 1Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Avon Orthopaedic Centre, Southmead Hospital, Bristol BS10 5NB, UK. V.Wylde@bristol.ac.uk

BMC Musculoskeletal Disorders
|November 15, 2012
PubMed
Summary
This summary is machine-generated.

This study compares function assessment tools after joint replacement surgery, evaluating their alignment with the International Classification of Functioning, Disability and Health (ICF) domains. Findings will guide selection of the most effective outcome measures for patients undergoing joint replacement.

Related Experiment Videos

Last Updated: May 16, 2026

The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve
09:51

The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve

Published on: September 7, 2022

Area of Science:

  • Orthopaedic surgery outcomes research
  • Rehabilitation science
  • Health measurement

Background:

  • Joint replacement is effective for advanced arthritis, but some patients experience poor outcomes.
  • Existing functional assessment tools often lack a clear theoretical basis.
  • The International Classification of Functioning, Disability and Health (ICF) provides a framework for understanding function.

Purpose of the Study:

  • To compare the properties and responsiveness of commonly used outcome tools for assessing function after joint replacement.
  • To examine how well these tools align with the International Classification of Functioning, Disability and Health (ICF) domains.
  • To explore changes in functional measures over time post-surgery.

Main Methods:

  • Recruited 263 patients undergoing lower limb joint replacement.
  • Assessed function using self-report (WOMAC, A-IMPART, SF-12, MYMOP2), clinician-administered (AKSS, Harris Hip Score), and performance-based measures with motion analysis (inertial sensors).
  • Collected data pre-surgery and at 3 months and 1 year post-surgery; statistical analysis focused on measure relationships, responsiveness, and changes over time.

Main Results:

  • A range of tools are available for assessing function before and after joint replacement.
  • Limited comparative data exists on the properties and responsiveness of these diverse measures.
  • This study provides data to inform the selection of appropriate functional outcome assessments.

Conclusions:

  • This study provides crucial comparative data on the properties and responsiveness of various functional outcome measures used after joint replacement.
  • The findings will help researchers and clinicians select the most appropriate tools aligned with the ICF framework.
  • Understanding these measures' performance is essential for accurately evaluating joint replacement outcomes.