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Maternal fecundity and asthma among offspring-is the risk programmed preconceptionally? Retrospective observational
Maijakaisa Harju1, Leea Keski-Nisula, Kaisa Raatikainen
1Department of Obstetrics and Gynaecology, Kuopio University Hospital, Kuopio, Finland. maija.harju@kuh.fi
Objective:
To evaluate the association between maternal fecundity factors and time to pregnancy and risk of asthma in offspring.
Design:
Retrospective observational hospital-based birth cohort study.
Setting:
A university-based obstetrics and gynecology department.
Patient(S):
A total of 40,914 women, who delivered between 1989 and 2007, were linked with the register for asthma reimbursement (n = 2,577) for their offspring. Fecundity factors were recorded during pregnancy. Logistic regression analyses were used.
Intervention(S):
None.
Main Outcome Measure(S):
Asthma among offspring.
Result(S):
The risk of asthma was significantly increased if the mother had any infertility problems (adjusted odds ratio [adjusted OR] 1.39, 95% confidence interval [CI] 1.19-1.63), medical infertility treatment (aOR 1.43, 95% CI 1.13-1.80), or any infertility treatment (aOR 1.50, 95% CI 1.26-1.79). The risk of asthma among offspring was also higher among mothers who had more than two miscarriages (aOR 1.25, 95% CI 1.04-1.51) and time to pregnancy over 3 months (aOR 1.25, 95% CI 1.07-1.45).
Conclusion(S):
These findings suggest that maternal subfertility exposes offspring to an increased risk of asthma.
Clinical Trial Registration Number:
The study is registered in Kuopio University Hospital register (TUTKI): ID 5302448.
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