Related Experiment Video
Updated: May 16, 2026
03:05
Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia
Published on: February 16, 2024
Prognostic factors and recurrence pattern in node-negative advanced gastric cancer
1Department of Surgery, Ulsan University College of Medicine and Asan Medical Centre, 388-1, Pungnap 2-dong, Songpa-ku, Seoul 138-736, Republic of Korea.
Summary
For node-negative advanced gastric cancer (AGC), tumor differentiation and serosa involvement are key prognostic factors. These elements help predict recurrence patterns and guide decisions on adjuvant therapy for better patient outcomes.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Oncology
Background:
- Node-negative advanced gastric cancer (AGC) patients have better survival but are still at risk of recurrence.
- Adjuvant therapy may benefit a subset of these patients.
- Identifying prognostic factors is crucial for tailoring treatment strategies.
Purpose of the Study:
- To evaluate prognostic factors in node-negative advanced gastric cancer (AGC).
- To analyze the recurrence patterns in node-negative AGC patients.
- To identify criteria for stratifying patients for adjuvant therapy.
Main Methods:
- Retrospective review of 424 patients with node-negative AGC undergoing curative gastrectomy.
- Exclusion criteria included T4b tumors, prior recurrence, remnant stomach tumors, <15 lymph nodes, and neoadjuvant chemotherapy.
- Analysis of prognostic factors and recurrence patterns based on clinicopathological data.
Main Results:
- Univariate analysis showed invasion depth, undifferentiated histology, signet ring cell type, and tumor size >6.3 cm correlated with poorer prognosis.
- Multivariate analysis identified differentiation and depth of invasion (especially serosa involvement) as significant prognostic factors.
- Five-year survival rates varied significantly based on differentiation and invasion depth, ranging from 98% to 72% (P < 0.01).
- Recurrence patterns differed: peritoneal seeding associated with diffuse type and deeper invasion; hematogenous metastasis with intestinal type and specific invasion depths.
Conclusions:
- Tumor differentiation and serosa involvement are significant prognostic factors in node-negative AGC.
- These factors are critical for stratifying patients who may benefit from adjuvant treatment.
- Understanding recurrence patterns based on Lauren's type and invasion depth can inform treatment strategies.
