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[Classification of dermatophytes by mating type (MAT) gene analysis].
1Department of Pathobiology, Nihon University School of Veterinary Medicine, Japan.
Medical Mycology Journal
|November 15, 2012
Summary
Anthropophilic Trichophyton mentagrophytes likely evolved from the zoophilic Arthroderma vanbreuseghemii (+) mating strain. This finding is based on the detection of mating type genes in dermatophyte isolates.
Area of Science:
- Medical Mycology
- Molecular Biology
- Evolutionary Biology
Context:
- Trichophyton mentagrophytes exhibits distinct zoophilic and anthropophilic forms.
- Zoophilic T. mentagrophytes are linked to teleomorphs Arthroderma benhamiae, A. simii, and A. vanbreuseghemii.
- Anthropophilic T. mentagrophytes, like T. mentagrophytes var. interdigitale, lack identified teleomorphs.
Purpose:
- To investigate the evolutionary origins of anthropophilic T. mentagrophytes.
- To differentiate zoophilic and anthropophilic strains using mating type (MAT) genes.
- To determine the ancestral mating type of anthropophilic T. mentagrophytes.
Summary:
- Mating type (MAT) genes (MAT1-1 and MAT1-2) were analyzed in zoophilic and anthropophilic dermatophytes.
- MAT1-1 was found in zoophilic strains, while MAT1-2 was present in all human isolates and some animal isolates.
- The MAT1-2 gene was detected in Arthroderma vanbreuseghemii (+) mating type strains from animal isolates.
Impact:
- Suggests anthropophilic T. mentagrophytes evolved from the A. vanbreuseghemii (+) mating strain.
- Provides molecular evidence for the lineage of human-adapted dermatophytes.
- Enhances understanding of fungal evolution and host adaptation.
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