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Paediatric lymphoma in China: a clinicopathological study of 213 cases
Jia Wang1, Xv Wu, Yuetian Shen
1Department of Pathology, Shanghai Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Insights
Pediatric lymphoma in China shows distinct patterns, with non-Hodgkin's lymphoma (NHL) being more common than Hodgkin's lymphoma (HL). These findings suggest unique ethnic or geographic variations in pediatric lymphoma presentation.
Area of Science:
- Oncology
- Pediatric Hematology/Oncology
- Epidemiology
Background:
- Lymphoma is a significant malignancy in children.
- Understanding geographic variations in lymphoma subtypes is crucial for diagnosis and treatment.
Purpose of the Study:
- To evaluate the characteristics of pediatric lymphoma in China.
- To compare the incidence and subtypes of pediatric lymphoma in China with Western countries and other Asian nations.
Main Methods:
- Retrospective review of pathological files of pediatric lymphoma patients (<12 years) at Shanghai Xinhua Hospital (1982-2009).
- Statistical analysis using SPSS version 11.0.
Main Results:
- Non-Hodgkin's lymphoma (NHL) accounted for 82.6% of cases, while Hodgkin's lymphoma (HL) comprised 17.4%.
- NHL cases were predominantly diffuse, high-grade, with 33.5% involving extra-nodal sites. T-cell lymphomas were most common (56.6%), followed by B-cell (43.3%).
- Lymphoblastic lymphoma (50.6%), Burkitt's lymphoma (28.4%), and anaplastic large cell lymphoma (12.5%) were the main NHL subtypes. Pediatric HL mirrored adult disease patterns.
Conclusions:
- Pediatric lymphoma in China exhibits differences in HL and Burkitt's lymphoma incidence compared to Western populations.
- The histological subtype distribution of NHL in China aligns more closely with Japan than Pakistan, suggesting ethnic or geographic influences.
Aim:
This retrospective study was conducted to evaluate information on paediatric lymphoma in China.
Methods:
We reviewed the pathological files of patients less than 12 years of age with lymphoma in Shanghai Xinhua Hospital from January 1982 to June 2009. SPSS version 11.0 was used to analyse the results.
Results:
Of the 213 subjects, 176 (82.6%) had non-Hodgkin's lymphoma (NHL) and 37 (17.4%) had Hodgkin's lymphoma (HL). All NHL cases had diffuse and high grade tumours, and 33.5% of these tumours primarily involved extra-nodal sites. Of the NHL cases, 56.6%, 43.3%, and 1.7% were derived from T, B, and null cells, respectively. Lymphoblastic lymphoma (LL, 50.6%), Burkitt's lymphoma (BL, 28.4%), and anaplastic large cell lymphoma (ALCL, 12.5%) comprised the majority of the NHL cases. A significant difference was found in the frequency of stage I/II cases between LL and ALCL. Paediatric HL resembled the disease in adults.
Conclusions:
Paediatric lymphoma in China is different from that in Western countries with respect to the incidence rate of HL and BL. The distribution pattern of NHL histological subtypes is more similar to that in Japan than that in Pakistan. These features suggest ethnic or geographic variations.
