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Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
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Vitamin D directly regulates Mdm2 gene expression in osteoblasts

Hankui Chen1, Grant Reed, Janete Guardia

  • 1Department of Biochemistry, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, IL 60515, United States.

Biochemical and Biophysical Research Communications
|November 15, 2012
PubMed
Summary

1,25-dihydroxy vitamin D3 activates Mdm2 gene expression via the P2 promoter in MC3T3 cells. This vitamin D receptor-mediated upregulation of Mdm2 requires the tumor suppressor p53.

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