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Updated: May 16, 2026
Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
Published on: December 1, 2020
Chemical probes for drug-resistance assessment by binding competition (RABC): oseltamivir susceptibility evaluation
Ting-Jen R Cheng1, Shi-Yun Wang, Wen-Hsien Wen
1The Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Abstract:
The wizard of OS (resistance): the binding difference of neuraminidase inhibitors (zanamivir versus oseltamivir (OS)) was used to establish an assay to identify the influenza subtypes that are resistant to OS but still sensitive to zanamivir. This assay used a zanamivir-biotin conjugate to determine the OS susceptibility of a wide range of influenza viruses and over 200 clinical isolates.
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