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Related Experiment Video

Updated: May 16, 2026

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

Corticosteroids and open-angle glaucoma in the elderly: a population-based cohort study.

Michael W Marcus¹, Rogier P H M Müskens, Wishal D Ramdas

¹Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

|November 15, 2012

Summary

This study found no link between corticosteroid use and open-angle glaucoma (OAG) in the elderly. Different steroid types, including ophthalmic, inhaled, nasal, oral, and ointments, did not increase OAG incidence in this population.

Related Experiment Videos

Last Updated: May 16, 2026

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

Area of Science:

Ophthalmology
Pharmacology
Geriatrics

Background:

The role of corticosteroid-induced open-angle glaucoma (OAG) in the general population remains unclear.
It is unknown if OAG is limited to susceptible individuals or a significant public health concern.

Purpose of the Study:

To investigate the association between corticosteroid use and the incidence of OAG in an elderly population.
To determine if various forms of steroid administration contribute to OAG development.

Main Methods:

Prospective population-based cohort study of 3,939 participants aged 55+ from the Rotterdam Study.
Ophthalmic examinations and continuous monitoring of corticosteroid use (ophthalmic, inhaled, nasal, oral, ointments) over approximately 10 years.
Logistic regression models were used to assess the association between steroid use and incident OAG, adjusting for relevant covariates.

Main Results:

During a mean follow-up of 9.8 years, 2.8% of participants developed OAG.
No statistically significant association was found between the use of ophthalmic, inhaled, nasal, oral steroids, or steroid ointments and the incidence of OAG.
Odds ratios for OAG ranged from 0.70 to 1.26 across different steroid classes, with p-values generally above 0.05.

Conclusions:

This study found no evidence that corticosteroid use, across various administration routes, is associated with an increased incidence of open-angle glaucoma in the elderly population.
The findings suggest that corticosteroid-induced OAG may not be a significant contributor to the overall burden of OAG in the general elderly population.