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Updated: May 8, 2026
09:43
Purification of H3 and H4 Histone Proteins and the Quantification of Acetylated Histone Marks in Cells and Brain Tissue
Published on: November 30, 2018
Histone acetylation as a therapeutic target
B Ruthrotha Selvi1, Snehajyoti Chatterjee, Rahul Modak
1Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, P.O., Bangalore, 560 064, India.
Sub-Cellular Biochemistry
|November 15, 2012
Summary
Epigenetics research reveals histone acetylation
Area of Science:
- Epigenetics and molecular biology
- Gene regulation and disease mechanisms
Background:
- Epigenetic modifications are crucial for transcriptional regulation and gene expression.
- Dysfunctional epigenetic marks are implicated in various disease states.
- Epigenetic therapy is emerging as a significant therapeutic strategy.
Purpose of the Study:
- To review the role of histone acetylation in biological processes.
- To explore the modulation of histone acetylation by small molecules.
- To highlight histone acetylation as a potential therapeutic target.
Main Methods:
- Literature review of epigenetic research.
- Analysis of studies on histone acetylation and gene expression.
- Examination of small molecule modulators of acetylation.
Main Results:
- Histone acetylation acts as a key epigenetic mark.
- Acetylation influences both normal and abnormal gene expression.
- Small molecules can effectively modulate histone acetylation.
Conclusions:
- Histone acetylation is a critical epigenetic mechanism.
- Targeting histone acetylation offers therapeutic potential.
- Further research into acetylation-based therapies is warranted.
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These groups modify specific amino acids in a protein.
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