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Total spontaneous resolution by deracemization of isoindolinones

Fumitoshi Yagishita1, Hiroki Ishikawa, Tatsuo Onuki

  • 1Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, Yayoi-cho, Inage-ku, Japan.

Angewandte Chemie (International Ed. in English)
|November 15, 2012
PubMed
Summary

Researchers resolved 3-hydroxy-3-phenylisoindolin-1-ones using dynamic preferential crystallization. This method achieved high enantiomeric excess (ee) values through racemization and selective crystallization.

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