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Related Experiment Video

Updated: May 16, 2026

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG
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Secondary signal change and an apparent diffusion coefficient decrease of the substantia nigra after striatal

Makoto Nakajima1, Yuichiro Inatomi, Takashi Okigawa

  • 1SPS3 Coordinating Centre, Division of Neurology, University of British, Columbia, S169-2211 Wesbrook Mall, Vancouver, British Columbia, V6T 2B5, Canada. nakazima04@gmail.com

Stroke
|November 15, 2012
PubMed
Summary
This summary is machine-generated.

Secondary signal changes in the substantia nigra after striatal infarction are linked to globus pallidus lesions or emboligenic diseases. This diffusion-weighted imaging finding does not predict clinical outcome in stroke patients.

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Published on: March 17, 2016

Area of Science:

  • Neuroimaging
  • Stroke Neurology
  • Diffusion-weighted Imaging

Background:

  • Diffusion-weighted imaging (DWI) can detect secondary signal changes in the substantia nigra following ipsilateral striatal infarction, indicated by decreased apparent diffusion coefficient (ADC).
  • Predictors for this DWI finding remain largely unknown.

Purpose of the Study:

  • To identify clinical predictors of substantia nigra ADC reduction after acute striatal infarction.
  • To investigate the relationship between substantia nigra ADC changes and clinical outcomes.

Main Methods:

  • Assessed 98 stroke patients with acute ischemic lesions in basal ganglia, external, or internal capsule.
  • Analyzed bilateral substantia nigra ADC values from follow-up MRI, clinical factors, and patient outcomes.
  • Excluded 19 patients with follow-up MRI within 3 days due to lack of significant ADC change.

Main Results:

  • 21 out of 79 patients (26.6%) showed decreased substantia nigra ADC.
  • Independent predictors for decreased ADC included globus pallidus lesions (OR 12.90) and emboligenic diseases (OR 6.95).
  • No significant difference in clinical outcome at 3 months was observed between groups.

Conclusions:

  • Reduced substantia nigra ADC after acute striatal infarction is associated with globus pallidus involvement and emboligenic diseases.
  • This imaging finding does not appear to correlate with the patient's clinical prognosis.