Related Experiment Video
Updated: May 16, 2026

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
Published on: July 19, 2018
Association between depression, nutritional status, and inflammatory markers in peritoneal dialysis patients
Havva Cilan1, Murat Hayri Sipahioglu, Nilüfer Oguzhan
1Department of Nephrology, Erciyes University Medical Faculty, Kayseri, Turkey. havvacilan@gmail.com
Background:
To investigate the relationship between depression, nutritional status, and inflammatory markers in patients on peritoneal dialysis (PD).
Patients And Methods:
This prospective study included 40 PD patients and 20 healthy people. The severity of depressive symptoms was assessed using the Beck depression inventory, the Hamilton depression rating scale, and the Hamilton anxiety rating scale. The depressive patients received antidepressant drug for 8 weeks. Blood samples were taken before and after antidepressant treatment for the high-sensitive C-reactive protein (hs-CRP), interleukin (IL)-1, IL-6, and tumor necrosis factor-α (TNF-α) levels.
Results:
Ten (25%) of the 40 PD patients had depression. No significant difference was determined between depressive patients and nondepressive patients. The mean erythrocyte sedimentation rate was higher in depressive patients. There was no significant difference for other inflammation parameters, including hs-CRP, TNF-α, IL-1, and IL-6, between depressive patients and nondepressive patients. In the depressive patients, we did not observe any significant change in nutritional parameters after antidepressant treatment. When we evaluated inflammation parameters of the depressive patients before and after antidepressant treatment, only IL-1 and IL-6 levels were significantly increased after antidepressant treatment.
Conclusion:
The depressive disorder in PD patients is a common psychopathology and has no significant effects on nutritional status and inflammation.
Related Concept Videos
Peritoneal Dialysis III: Nursing Management
Chronic Kidney Disease III: Interprofessional Care
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Nephrotic Syndrome III : Nursing Management
Peptic Ulcer Disease III: Clinical Manifestations and Complications