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PolySac3DB: an annotated data base of 3 dimensional structures of polysaccharides
1Centre de Recherches sur les Macromolécules Végétales (CERMAV*) Centre National de la Recherche Scientifique, Grenoble Cedex 9, BP 53X, F-38041, France.
BMC Bioinformatics
|November 16, 2012
Summary
PolySac3DB is a new database detailing 157 polysaccharide 3D structures. This resource aids research in drug design, vaccine development, and material science by providing structural data and visualization tools.
Area of Science:
- Biochemistry
- Structural Biology
- Bioinformatics
Background:
- Polysaccharides are vital biomolecules with diverse roles in biological and technological processes.
- Understanding polysaccharide three-dimensional (3D) structure is crucial for studying host-pathogen interactions, drug design, vaccine development, and material science.
Purpose of the Study:
- To establish PolySac3DB, a comprehensive annotated database of polysaccharide 3D structures.
- To provide a centralized resource for accessing and visualizing detailed polysaccharide structural information.
Main Methods:
- Extensive literature screening to collect 157 polysaccharide entries.
- Systematic organization of data into 18 polysaccharide families.
- Inclusion of detailed structural information, experimental methods, and downloadable atomic coordinates.
Main Results:
- The PolySac3DB database contains 157 annotated 3D polysaccharide structures.
- Data includes repeat units, glycosidic linkages, unit cell dimensions, space group, and helix type.
- A user-friendly graphical user interface (GUI) with interactive displays and search options is provided.
Conclusions:
- PolySac3DB serves as a valuable repository for detailed 3D polysaccharide structure information.
- The database is accessible via a web interface with a search engine.
- It facilitates research in various fields by providing easy access to structural data and visualization tools.
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