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Grape seed extract as a potential remineralizing agent: a comparative in vitro study
Shiny Benjamin1, Roshni Sharma, Sabeena Susan Thomas
1Department of Conservative Dentistry and Endodontics, Vydehi Institute of Dental Sciences, Bengaluru, Karnataka, India.
The Journal of Contemporary Dental Practice
|November 16, 2012
Summary
Grape seed extract (GSE) shows promise in reversing early tooth decay by promoting remineralization. This study found GSE more effective than other treatments for artificial root caries lesions.
Area of Science:
- Dental Science
- Biomaterials Research
Background:
- Early tooth decay (caries) can be managed with remineralization therapies.
- Grape seed extract (GSE) is being explored as a novel remineralizing agent.
Purpose of the Study:
- To evaluate the remineralizing potential of GSE on artificial root caries lesions.
- To compare GSE efficacy against established agents like sodium monofluorophosphate.
Main Methods:
- Human tooth root sections were subjected to artificial caries induction.
- Specimens were treated with GSE, sodium monofluorophosphate, calcium glycerophosphate, or a control.
- An in vitro pH cycling model simulated oral conditions over 8 days.
- Confocal laser scanning microscopy assessed remineralization and demineralization levels.
Main Results:
- Grape seed extract demonstrated superior performance in promoting remineralization.
- GSE exhibited reduced demineralization compared to control and other tested agents.
Conclusions:
- Grape seed extract effectively promotes remineralization of artificial root caries.
- GSE represents a potential new option for dental caries treatment and prevention.
