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Updated: May 16, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
NF-κB activation by equine arteritis virus is MyD88 dependent and promotes viral replication
Amin Mottahedin1, Maruthibabu Paidikondala, Harindranath Cholleti
1Department of Virology, Immunobiology and Parasitology, National Veterinary Institute, Ulls Väg 2B, SE-751 89 Uppsala, Sweden.
Abstract:
NF-κB, a family of transcription factors involved in different cell functions and immune responses is targeted by viruses. The mechanism of NF-κB signalling and its role in replication of EAV have not been investigated. We demonstrate that EAV infection in BHK-21 cells activates NF-κB, and this activation was found to be mediated through the MyD88 pathway. Infection of IKKβ(-/-) murine embryo fibroblasts (MEFs), which are deficient in NF-κB signalling, resulted in lower virus titre, less cytopathic effect, and reduced expression of viral proteins. These findings implicate the MyD88 pathway in EAV-induced NF-κB activation and suggest that NF-κB activation is essential for efficient replication of EAV.
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