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15:04
Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
Published on: January 19, 2019
Anticancer steroids: linking natural and semi-synthetic compounds
Jorge A R Salvador1, João F S Carvalho, Marco A C Neves
1Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, Polo das Ciências da Saúde, 3000-508, Coimbra, Portugal. salvador@ci.uc.pt samelo@ff.uc.pt
Natural Product Reports
|November 16, 2012
Summary
Steroids exhibit significant anticancer properties due to their diverse structures and ability to target various biological pathways. This review highlights key discoveries in steroid anticancer drugs from the past decade.
Area of Science:
- Biochemistry
- Pharmacology
- Organic Chemistry
Background:
- Steroids are naturally occurring organic compounds found in animals, plants, and fungi.
- They possess significant therapeutic value across a wide range of pathologies.
- Their structural diversity allows interaction with numerous biological targets and pathways.
Purpose of the Study:
- To provide an overview of the anticancer activity of steroids.
- To highlight recent discoveries in steroid anticancer drugs and leads.
- To cover the most relevant findings from the last decade.
Main Methods:
- Literature review of scientific publications.
- Analysis of studies on steroid anticancer activity.
- Synthesis of information from 668 references.
Main Results:
- Steroids demonstrate notable anticancer potential.
- Diverse molecular structures of steroids contribute to their efficacy.
- Interaction with multiple biological targets and pathways is key to their action.
Conclusions:
- Steroids represent a promising class of compounds for cancer therapy.
- Continued research into steroid anticancer drugs is warranted.
- The structural versatility of steroids offers opportunities for novel drug development.
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