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[Managing cutaneous toxicities of targeted therapies]

Yoshio Kiyohara1

  • 1Division of Dermatology, Shizuoka Cancer Center Hospital, Shizuoka 411-8777, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|November 16, 2012
PubMed

Insights

Molecularly targeted cancer therapies can cause skin side effects, impacting patient quality of life. Early intervention with skincare and multidisciplinary team collaboration is key to managing these reactions and ensuring treatment success.

Area of Science:

  • Oncology and Dermatology
  • Cancer Therapeutics
  • Cutaneous Medicine

Context:

  • Molecularly targeted therapies are increasingly used for cancer treatment.
  • These therapies frequently cause unique cutaneous side effects like hand-foot syndrome, rash, dry skin, and paronychia.
  • These side effects can significantly impair patients' quality of life and lead to treatment discontinuation.

Purpose:

  • To highlight the common cutaneous side effects associated with molecularly targeted cancer therapies.
  • To emphasize the importance of early diagnosis and management of these side effects.
  • To advocate for a multidisciplinary approach involving oncologists, dermatologists, and nurses for preventative skincare and treatment.

Summary:

  • Cutaneous side effects are a common challenge in molecularly targeted cancer therapy.
  • Management strategies include emollients, topical antibiotics, corticosteroids, and antihistamines.
  • Preventative skincare focusing on moisture retention, cleanliness, and protection is crucial.

Impact:

  • Effective management of skin toxicities can improve patient quality of life.
  • Proactive and collaborative care can prevent treatment termination, enhancing anticancer therapy success.
  • This approach balances therapeutic benefits with the management of cutaneous reactions.

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