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Updated: May 16, 2026

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock
Published on: October 28, 2022
[Renal failure after gastrointestinal hemorrhage: case 10/2012]
History And Admission Findings:
We report on a 78-year-old female patient, who presented to the emergency department with nausea and vomiting.
Investigations:
Endoscopy of the upper gastrointestinal tract revealed gastric erosions and duodenal ulcers. The patient had iron deficiency anemia.
Diagnosis, Treatment And Course:
Following treatment with a proton pump inhibitor (PPI) the patient developed fever, signs of inflammation and oliguric renal failure. In the urine-dipstick there was minimal hematuria and leukocyturia. Urinary protein-differentiation revealed tubular proteinuria with excretion of α1-microglobulin. Renal biopsy showed interstitial nephritis with infiltration of eosinophilic granulocytes. After stopping treatment with PPI and commencing glucocorticoid therapy, the patient recovered fully from renal failure.
Conclusions:
Allergic interstitial nephritis following PPI treatment is an important differential diagnosis of renal failure of unknown cause and has a good prognosis when promptly diagnosed and treated.
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