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Delayed leptin administration after stroke induces neurogenesis and angiogenesis
1Department of Human Nutrition and Metabolism, Hebrew University Hadassah Medical Center, Jerusalem, Israel.
Journal of Neuroscience Research
|November 16, 2012
Summary
Delayed leptin administration after stroke promotes neurogenesis and angiogenesis but does not improve functional recovery. Early leptin treatment is crucial for beneficial effects post-stroke.
Area of Science:
- Neuroscience
- Endocrinology
- Regenerative Medicine
Background:
- Leptin, an AMPK inhibitor, offers neuroprotection, neurogenesis, and angiogenesis when given early post-stroke.
- The effects of delayed leptin administration on stroke recovery remain unclear.
Purpose of the Study:
- To investigate the impact of delayed leptin administration on neurogenesis and angiogenesis after stroke.
- To determine if late-stage leptin treatment can improve functional outcomes following stroke.
Main Methods:
- Sabra mice received photothrombotic stroke and were treated with leptin or vehicle 10 days later.
- Neurogenesis was assessed using bromodeoxyuridine labeling.
- Angiogenesis and functional outcomes were evaluated via immunohistochemistry and neurological severity scoring.
Main Results:
- Leptin treatment significantly increased proliferating cells, newborn neurons, and glia in the stroke-affected brain regions.
- Leptin administration also enhanced blood vessel formation in the cortex surrounding the lesion.
- Despite increased neurogenesis and angiogenesis, no significant functional improvement was observed in leptin-treated mice.
Conclusions:
- Leptin administration, even when delayed by 10 days, stimulates neurogenesis and angiogenesis post-stroke.
- The beneficial effects of leptin in stroke recovery appear primarily linked to its early neuroprotective actions, not late-stage pro-neurogenic or pro-angiogenic effects.
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