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Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
15:05

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation

Published on: May 20, 2020

Consequences of replacing EGFR juxtamembrane domain with an unstructured sequence

Lijuan He1, Kalina Hristova

  • 1Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

Scientific Reports
|November 16, 2012
PubMed
Summary

The epidermal growth factor receptor (EGFR) juxtamembrane domain is crucial for its phosphorylation. Replacing this domain abolishes EGFR tyrosine phosphorylation, impacting signaling.

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