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Estimation of protein secondary structure from circular dichroism spectra: a critical examination of the CONTIN
A Bobba1, P Cavatorta, M Attimonelli
1Centro Studio sui Mitocondri e Metabolismo Energetico, CNR, Bari, Italy.
Protein Sequences & Data Analysis
|March 1, 1990
Abstract:
The computer program CONTIN uses the Provencher and Glöckner procedure to calculate protein secondary structure from circular dichroism spectra. We have tested this program with peptides and proteins in which unfolding was either induced by denaturing treatment or was already present. Results indicate that the program does not clearly discriminate between the ordered and the unordered states of a protein.