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Related Concept Videos

Decreased Body Temperature01:29

Decreased Body Temperature

A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by sustained extreme cold exposure, and severe...

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Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
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HIFU treatment time reduction through heating approach optimisation.

Joshua Coon1, Nick Todd, Robert Roemer

  • 1Department of Physics and Astronomy, University of Utah, 115 South 400 East, Salt Lake City, UT 84112-0830, USA. coon@eng.utah.edu

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
|November 17, 2012
PubMed
Summary
This summary is machine-generated.

Concentrated heating using High-Intensity Focused Ultrasound (HIFU) significantly reduces treatment times and minimizes normal tissue heating compared to fractionated volumetric scanning. Optimizing heating parameters enhances these benefits.

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Evaluation of the Feasibility, Safety, and Accuracy of an Intraoperative High-intensity Focused Ultrasound Device for Treating Liver Metastases

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Area of Science:

  • Medical physics
  • Oncology
  • Ultrasound technology

Background:

  • High-Intensity Focused Ultrasound (HIFU) is an emerging non-invasive therapeutic technology.
  • Optimizing HIFU treatment parameters is crucial for improving efficacy and patient outcomes.
  • Understanding the impact of different heating strategies on treatment time and tissue effects is essential.

Purpose of the Study:

  • To evaluate treatment time reductions with High-Intensity Focused Ultrasound (HIFU) by comparing single, discrete pulses versus volumetric scanning.
  • To assess the influence of focal zone heating locations, number of cycles, and heating times on HIFU treatment efficiency.
  • To investigate the effects of focal zone size, increased tissue absorptivity, and optimization techniques on HIFU treatment.

Main Methods:

  • Simulated treatments of homogeneous tumors with varying shapes and sizes using concentrated (single pulse) and fractionated (volumetric scanning) heating approaches.
  • Compared treatment times and normal tissue heating between concentrated and fractionated HIFU methods.
  • Employed simultaneous, collective, and sequential single pulse optimization techniques to minimize treatment durations.

Main Results:

  • Optimized concentrated heating demonstrated shorter treatment times and reduced normal tissue heating compared to optimized fractionated heating.
  • Significant changes in tissue absorptivity due to heating altered the optimal sequence of focal zone locations in scan paths.
  • Volumetric scanning, a type of fractionated heating, was consistently less efficient than concentrated heating.

Conclusions:

  • Concentrated heating with HIFU offers substantial reductions in treatment time.
  • Concentrated heating results in less collateral heating of surrounding normal tissues compared to fractionated scanning methods.
  • HIFU optimization strategies, particularly concentrated heating, are key to improving non-invasive cancer treatment efficiency.