Two-stage amplification of receptors using a multilevel orthogonal/simultaneous dynamic combinatorial library
Andrea M Escalante1, A Gastón Orrillo, Ignacio Cabezudo
1Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina.
Organic Letters
|November 17, 2012
Abstract:
Sequential activation of different reversible exchange reactions in a dynamic combinatorial library allows directed exploration of the chemical space: initially a macrocyclic scaffold is selected by the template and finally side chain and conformational constrains are introduced into such a scaffold.
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