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Related Concept Videos

Portal Hypertension01:22

Portal Hypertension

Portal hypertension is an increase in blood pressure within the portal venous system. Normally, this pressure is less than 5 mmHg. It is considered clinically significant when it rises above 10 mmHg. At this threshold, complications from altered blood flow and venous congestion emerge.EtiologyPortal hypertension arises from conditions that impede blood flow through the liver. The most common cause is cirrhosis, in which chronic liver injury leads to fibrotic scarring. This fibrosis narrows or...
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Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...

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Related Experiment Video

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Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
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Published on: December 18, 2012

Behcet's Syndrome.

Sam R Dalvi1, Resit Yildirim, Yusuf Yazici

  • 1Division of Rheumatology, Duke University Medical Center, Durham, NC, USA.

Drugs
|November 17, 2012
PubMed
Summary

Behcet's syndrome (BS) is a complex vasculitis affecting multiple organs. Treatment involves immunosuppression and varies based on disease severity and organ involvement.

Area of Science:

  • Rheumatology
  • Immunology
  • Genetics

Background:

  • Behcet's syndrome (BS) is a rare multisystem vasculitis.
  • Prevalent along the Silk Road, BS presents with oral/genital ulcers, skin lesions, uveitis, and organ-specific involvement.
  • Genetic factors like HLA-B51 and environmental triggers are implicated in BS pathogenesis.

Purpose of the Study:

  • To review clinical studies on Behcet's syndrome management.
  • To discuss treatment strategies, drug toxicities, and patient stratification.
  • To provide guidelines for vaccinations and thrombotic disease management in BS patients.

Main Methods:

  • Review of salient clinical studies for various drug classes used in BS treatment.
  • Assessment and stratification of patients based on clinical manifestations and disease severity.

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  • Discussion of drug toxicities, monitoring, and vaccination guidelines.

    • Main Results:

    • Serious BS manifestations often respond well to immunosuppressive therapy.
    • Treatment is highly variable, depending on disease severity and organ involvement.
    • Management requires a multidisciplinary approach, addressing common manifestations and thrombotic complications.

    Conclusions:

    • Behcet's syndrome management is complex and requires individualized, multidisciplinary care.
    • Effective treatment strategies exist for common BS manifestations and thrombotic events.
    • Understanding disease heterogeneity and patient stratification is key for optimal outcomes.