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Related Experiment Video

Updated: May 16, 2026

Correction of Presbyopia by Monocular Bi-Aspheric Ablation Profile

Published on: September 20, 2024

Higher-order aberrations and anisometropia.

Andreas Hartwig¹, David A Atchison, Hema Radhakrishnan

¹Faculty of Life Sciences, University of Manchester, UK.

Current Eye Research

|November 17, 2012

Summary

Higher-order aberrations (HOA) did not show a direct link to refractive error development in anisometropic eyes. This study found no significant correlation between HOA differences and refractive error progression in either isometropes or anisometropes.

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The Generation of Higher-order Laguerre-Gauss Optical Beams for High-precision Interferometry

Published on: August 12, 2013

Area of Science:

Ophthalmology
Optometry
Vision Science

Background:

Global myopia incidence is rising, with multiple factors contributing to myopization.
Understanding the role of higher-order aberrations (HOA) in refractive error development is crucial.
Investigating optical properties in anisometropic eyes may offer insights into refractive error progression.

Purpose of the Study:

To investigate the potential influence of higher-order aberrations (HOA) on refractive error development.
To compare HOA between anisometropic (unequal refractive error between eyes) and isometropic (equal refractive error) individuals.
To determine if interocular differences in HOA correlate with interocular differences in refractive error.

Main Methods:

Analyzed HOA up to the 4th order in 20 anisometropes and 20 isometropes using the Shack-Hartman i.Profiler.
Measured HOA for a 4 mm pupil and calculated Mean Spherical Equivalent (MSE) from subjective refraction.
Defined anisometropia as ≥1 D interocular difference in MSE and compared interocular HOA differences with MSE differences using correlations.

Main Results:

For isometropes, several HOA (oblique trefoil, vertical/horizontal coma, spherical aberration) showed significant interocular correlation.
In anisometropes, most HOA correlated significantly between eyes, excluding oblique secondary astigmatism and secondary astigmatism.
No significant correlations were found between interocular HOA differences and MSE when analyzing anisometropes and isometropes separately.

Conclusions:

The study did not find evidence that interocular differences in higher-order aberrations increase with greater interocular differences in refractive error.
The findings suggest that HOA differences may not be a primary driver of refractive error disparities between eyes.
Further research is needed to fully elucidate the complex relationship between ocular optics and refractive error development.