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Related Concept Videos

Diverticular Disease of the Colon01:27

Diverticular Disease of the Colon

Diverticular disease involves the formation of diverticula—small sac-like outpouchings of the colonic wall—and their complications. It most commonly affects the sigmoid colon due to higher intraluminal pressure and structural vulnerability. It results from structural weakness and increased pressure in the colon, producing pseudodiverticula that may remain silent or progress to inflammation and serious complications.Structure of DiverticulaIn diverticulosis, these outpouchings are...
Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Appendicitis01:19

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...

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Related Experiment Videos

[Pilonidal disease is a benign condition].

Helle Gad Midtgaard1, Susanne Eiholm

  • 1Kirurgisk Afdeling, Køge Sygehus, Lykkebækvej 1, Køge. hellegadl@hotmail.com

Ugeskrift for Laeger
|November 17, 2012
PubMed
Summary

Malignant transformation in pilonidal disease is rare, with only 75 reported cases globally. Routine histological examination is questionable, but investigate specimens from high-risk patients with chronic disease or specific risk factors.

Area of Science:

  • Surgical pathology
  • Oncology
  • Dermatology

Context:

  • Pilonidal disease, a common condition, rarely undergoes malignant transformation.
  • Malignancy in pilonidal disease is exceptionally rare, with only 75 cases documented worldwide.
  • No cases of malignant transformation in pilonidal disease have been reported in Denmark.

Purpose:

  • To evaluate the necessity of routine histological examination of surgical specimens from pilonidal disease.
  • To identify patient subgroups at higher risk for malignant transformation.
  • To guide diagnostic and management strategies for pilonidal disease.

Summary:

  • Malignant transformation in pilonidal disease is extremely rare, predominantly squamous cell carcinoma.
  • The cost-benefit of routine histological examination for all pilonidal surgery specimens is debatable.

Related Experiment Videos

  • High-risk patients, including those with long-standing disease, immunodeficiency, human papillomavirus (HPV) infection, or abnormal clinical presentation, warrant mandatory histological investigation.

    • Impact:

    • This study suggests a targeted approach to histological examination in pilonidal disease, optimizing resource allocation.
    • It emphasizes the importance of vigilance for rare malignancies in specific patient populations.
    • Findings can inform clinical guidelines and improve patient outcomes by focusing on high-risk individuals.