Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Assembly of Complex Microtubule Structures

Assembly of Complex Microtubule Structures

Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.

Neurons: The Axon

Neurons: The Axon

Axons are long, cytoplasmic processes of nerve cells capable of propagating electrical impulses known as action potentials. The cytoplasm or axoplasm of an axon contains neurofibrils, neurotubules, small vesicles, lysosomes, mitochondria, and various enzymes, all encased within the axolemma, the plasma membrane of the axon.
The axon attaches to the cell body at a cone-shaped elevation called the axon hillock. The initial part of the axon, closest to the hillock, is known as the initial segment.

Cell Motility through Blebbing

Cell Motility through Blebbing

Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...

The Movement of Organelles and Vesicles

The Movement of Organelles and Vesicles

In eukaryotic cells, cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These filaments serve as tracks for transporting cellular cargo. Specialized motor proteins use the chemical energy stored in adenosine triphosphate (ATP) for this transport. During interphase, microtubules are polarized, with the plus-end towards the cell periphery and the minus-end towards the cell center. Two microtubule-associated motor proteins,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Targeting notch signaling to restore neural development and behavior in mouse models of ASD.

Nature communications·2026

Same author

Dilated cardiomyopathy-associated RNA-binding motif protein 20 regulates long pre-mRNAs in neurons.

eLife·2026

Same author

Editorial overview: Molecular neuroscience.

Current opinion in neurobiology·2025

Same author

Molecular programs specifying properties and plasticity of parvalbumin interneuron innervation.

Current opinion in neurobiology·2025

Same author

Critical factors for flow cytometry analysis of the brain.

The FEBS journal·2025

Same author

Thoughts on mentoring trainees in neuroscience.

The European journal of neuroscience·2024

Same journal

AXIN1 and AXIN2 regulate the WNT-signaling landscape to promote distinct mesoderm programs.

Developmental cell·2026

Same journal

ARID1A terminates gastric regeneration to prevent cancer.

Developmental cell·2026

Same journal

Myc sustains sex-biased organ zonation in the Drosophila intestine.

Developmental cell·2026

Same journal

Two parallel neuronal circuits involving electrical synapse and DAF-7/TGF-β signaling regulate muscle autophagy in C. elegans.

Developmental cell·2026

Same journal

Menstruation: Once unspoken but now uncovered, one cell type at a time.

Developmental cell·2026

Same journal

The ALS- and FTD-associated proteins annexin A11 and CHMP2B act sequentially in plasma membrane repair.

Developmental cell·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 16, 2026

Time-lapse Live Imaging and Quantification of Fast Dendritic Branch Dynamics in Developing Drosophila Neurons

Time-lapse Live Imaging and Quantification of Fast Dendritic Branch Dynamics in Developing Drosophila Neurons

Published on: September 25, 2019

Choreographing the axo-dendritic dance.

Peter Scheiffele¹, Takatoshi Iijima

¹Biozentrum, University of Basel, Klingelbergstrasse 50-70, 4056 Basel, Switzerland. peter.scheiffele@unibas.ch

Developmental Cell

|November 17, 2012

Summary

This summary is machine-generated.

Researchers discovered a developmental program that guides the formation of presynaptic terminals. This process is crucial for building connections between brain cells.

More Related Videos

Utilizing Combined Methodologies to Define the Role of Plasma Membrane Delivery During Axon Branching and Neuronal Morphogenesis

Utilizing Combined Methodologies to Define the Role of Plasma Membrane Delivery During Axon Branching and Neuronal Morphogenesis

Published on: March 16, 2016

Related Experiment Videos

Last Updated: May 16, 2026

Time-lapse Live Imaging and Quantification of Fast Dendritic Branch Dynamics in Developing Drosophila Neurons

Time-lapse Live Imaging and Quantification of Fast Dendritic Branch Dynamics in Developing Drosophila Neurons

Published on: September 25, 2019

Utilizing Combined Methodologies to Define the Role of Plasma Membrane Delivery During Axon Branching and Neuronal Morphogenesis

Utilizing Combined Methodologies to Define the Role of Plasma Membrane Delivery During Axon Branching and Neuronal Morphogenesis

Published on: March 16, 2016

Area of Science:

Neuroscience
Cell Biology
Developmental Biology

Background:

Neuronal synapse assembly requires intricate bidirectional communication between connected neurons.
Understanding the molecular mechanisms governing synapse formation is fundamental to neuroscience.

Discussion:

Ito-Ishida and colleagues elucidate a key morphogenetic program dictating presynaptic terminal development.
This study reveals novel insights into the spatial and temporal regulation of synaptic structure formation.

Key Insights:

A specific morphogenetic program orchestrates the assembly of presynaptic terminals.
This program involves coordinated signaling events essential for establishing functional neuronal connections.

Outlook:

Further research can explore the precise molecular players and signaling pathways involved in this program.
Understanding presynaptic development may offer therapeutic targets for neurological disorders characterized by synaptic dysfunction.