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Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes
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Epigenetic therapy leaps ahead with specific targeting of EZH2
1Department of Medicine, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA. amm2014@med.cornell.edu
Abstract:
The Polycomb epigenetic silencing protein EZH2 is affected by gain-of-function somatic mutations in B cell lymphomas. Two recent reports describe the development of highly selective EZH2 inhibitors and reveal mutant EZH2 as playing an essential role in maintaining lymphoma proliferation. EZH2 inhibitors are thus a promising new targeted therapy for lymphoma.
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