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Orally delivered cocaine as a reinforcer for rhesus monkeys
R A Meisch1, F R George, G A Lemaire
1Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center, Houston 77030.
Pharmacology, Biochemistry, and Behavior
|January 1, 1990
Abstract:
Orally delivered cocaine was established as a reinforcer for six rhesus monkeys. Cocaine and its vehicle, water, were available from separate spouts under independent concurrent fixed-ratio schedules. The positions of cocaine and water were reversed between spouts from session to session. Cocaine consistently maintained higher response rates than water. Cocaine concentration was systematically varied for three of the six monkeys tested, and cocaine intake (mg of drug/kg of body wt.) increased with increases in drug concentration.