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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...

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Related Experiment Video

Updated: May 16, 2026

Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry
14:02

Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry

Published on: April 21, 2017

Recent advances in cardiovascular proteomics.

Parveen Sharma1, Jake Cosme, Anthony O Gramolini

  • 1Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5G 1L6. parveen.sharma@utoronto.ca

Journal of Proteomics
|November 17, 2012
PubMed
Summary
This summary is machine-generated.

Cardiovascular proteomics offers new insights into heart disease. Advanced technologies enable detailed cardiac proteome analysis for novel diagnostic markers and therapeutic targets in cardiovascular diseases (CVDs).

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Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve
09:13

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve

Published on: June 14, 2017

Related Experiment Videos

Last Updated: May 16, 2026

Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry
14:02

Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry

Published on: April 21, 2017

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve
09:13

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve

Published on: June 14, 2017

Area of Science:

  • Proteomics and cardiovascular research
  • Biomarker discovery for heart conditions

Background:

  • Cardiovascular diseases (CVDs) are a leading global cause of mortality.
  • CVDs manifest as acute myocardial infarction (AMI) or chronic heart failure.
  • Traditional methods limit comprehensive cardiac proteome analysis.

Purpose of the Study:

  • To outline current insights from cardiovascular proteomics.
  • To discuss innovative technologies for cardiac protein analysis.
  • To highlight applications in CVD diagnosis and patient management.

Main Methods:

  • Advanced mass spectrometry for protein detection and analysis.
  • Improved isolation and enrichment techniques for organelles and membrane proteins.
  • Examination of protein complements in organelles (e.g., exosomes) and secreted proteins.

Main Results:

  • Detailed analysis of the cardiac proteome is now feasible.
  • Innovative technologies allow examination of specific protein compartments.
  • Foundational studies provide tools for CVD research.

Conclusions:

  • Cardiovascular proteomics is advancing diagnostic marker discovery.
  • New methods for cardiac patient management are emerging.
  • Identification of novel drug targets for CVDs is a key outcome.