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Updated: May 16, 2026

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
16:31

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

Published on: June 6, 2011

Hypovolemic shock resuscitation.

Leslie Kobayashi1, Todd W Costantini, Raul Coimbra

  • 1Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego School of Medicine, San Diego, CA 92103, USA.

The Surgical Clinics of North America
|November 17, 2012
PubMed
Summary
This summary is machine-generated.

Recent advances in hemorrhagic shock resuscitation, including permissive hypotension and early blood transfusions, improve patient outcomes. These strategies, alongside hemostatic adjuncts, are now standard in trauma centers, reducing mortality and morbidity.

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Last Updated: May 16, 2026

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
16:31

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Published on: June 6, 2011

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09:09

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07:51

Standardized Hemorrhagic Shock Induction Guided by Cerebral Oximetry and Extended Hemodynamic Monitoring in Pigs

Published on: May 21, 2019

Area of Science:

  • Trauma resuscitation strategies
  • Hemorrhagic shock management
  • Coagulopathy assessment

Background:

  • Traditional resuscitation methods for hemorrhagic shock are evolving.
  • New approaches focus on minimizing fluid overload and optimizing blood product ratios.
  • Incorporation of hemostatic agents and advanced coagulopathy diagnostics is increasing.

Purpose of the Study:

  • To review recent advancements in hemorrhagic shock resuscitation.
  • To discuss the evidence supporting new resuscitation strategies.
  • To highlight the integration of these strategies into massive transfusion protocols.

Main Methods:

  • Review of current literature on hemorrhagic shock resuscitation.
  • Analysis of evidence for permissive hypotension, minimal crystalloid use, and early blood transfusion.
  • Evaluation of the role of hemostatic adjuncts and novel coagulopathy assessments.

Main Results:

  • Adoption of updated protocols in trauma centers has led to improved survival rates.
  • Specific strategies like higher plasma/platelet ratios and tranexamic acid show efficacy.
  • New methods for assessing coagulopathy aid in tailored resuscitation.

Conclusions:

  • Modern resuscitation protocols for hemorrhagic shock have demonstrably reduced mortality and morbidity.
  • Evidence supports the use of permissive hypotension, balanced blood product transfusion, and hemostatic adjuncts.
  • Institutional massive transfusion protocols are crucial for implementing these life-saving strategies.