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Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
External Anatomy of the Kidney01:21

External Anatomy of the Kidney

The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...

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Related Experiment Videos

[Kidney involvement in sarcoidosis].

T Stehlé1, J-J Boffa, P Lang

  • 1Inserm U955, service de néphrologie et transplantation, université Paris Est, hôpital Henri-Mondor, institut francilien de recherche en néphrologie et transplantation (IFRNT), AP-HP, 94010 Créteil, France. thstehle@gmail.com

La Revue De Medecine Interne
|November 17, 2012
PubMed
Summary

Sarcoidosis can cause kidney problems like granulomatous tubulointerstitial nephritis and glomerular disease. Early treatment with corticosteroids is crucial for managing renal complications and improving outcomes.

Keywords:
Calcium homeostasisGlomerular diseaseGranulomatous interstitial nephritisHoméostasie calciqueMaladie glomérulaireNéphrite interstitielle granulomateuseSarcoidosisSarcoïdose

Related Experiment Videos

Area of Science:

  • Nephrology
  • Immunology
  • Endocrinology

Context:

  • Sarcoidosis is a multisystemic inflammatory disease of unknown cause.
  • Renal manifestations are common in sarcoidosis patients.
  • Bone and mineral metabolism disorders, particularly vitamin D-related, are frequently associated.

Purpose:

  • To summarize the renal manifestations of sarcoidosis.
  • To discuss the impact of hypercalcemia on kidney injury.
  • To outline therapeutic strategies for renal sarcoidosis.

Summary:

  • Sarcoidosis frequently affects the kidneys, leading to conditions such as granulomatous tubulointerstitial nephritis (GTIN) and membranous nephropathy.
  • Hypercalcemia and hypercalciuria, driven by vitamin D metabolism dysregulation, are common and can cause acute kidney injury, nephrolithiasis, and nephrocalcinosis.
  • GTIN is the most prevalent renal lesion, potentially progressing to end-stage renal disease; early corticosteroid therapy is vital, especially with interstitial fibrosis.
  • Kidney transplant recipients with sarcoidosis face a high risk of GTIN recurrence, impacting graft survival.

Impact:

  • Highlights the significance of renal involvement in sarcoidosis management.
  • Emphasizes the need for early diagnosis and intervention to prevent irreversible kidney damage.
  • Provides insights into therapeutic approaches for sarcoidosis-associated kidney disease.