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Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
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Deep brain stimulation for dystonia.

Marie Vidailhet1, Marie-France Jutras, David Grabli

  • 1AP-HP, Department of Neurology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France. marie.vidailhet@psl.aphp.fr

Journal of Neurology, Neurosurgery, and Psychiatry
|November 17, 2012
PubMed
Summary
This summary is machine-generated.

Deep brain stimulation (DBS) using bilateral internal globus pallidus stimulation is effective for hyperkinetic disorders. However, evidence for dystonia requires further controlled studies to optimize patient and target selection.

Keywords:
Cerebral PalsyDystoniaMovement DisordersSurgery

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Area of Science:

  • Neurology
  • Neurosurgery
  • Movement Disorders

Background:

  • Bilateral internal globus pallidus stimulation shows promise for hyperkinetic disorders.
  • Current deep brain stimulation (DBS) data for dystonia primarily consists of uncontrolled case reports, hindering efficacy assessment.
  • Selecting optimal DBS targets for specific dystonia subtypes remains challenging.

Purpose of the Study:

  • To analyze the literature on DBS for dystonia based on expected outcomes.
  • To differentiate between DBS applications with strong evidence of benefit and those with less predictable results.
  • To guide the selection of dystonia patients who may benefit from DBS.

Main Methods:

  • Literature analysis of deep brain stimulation (DBS) for dystonia.
  • Categorization of studies based on evidence of favorable outcomes.
  • Review of results for primary dystonia, myoclonus-dystonia, tardive dystonia, and secondary dystonia.

Main Results:

  • Pallidal stimulation demonstrates a favorable risk/benefit ratio for primary dystonia, myoclonus-dystonia, and tardive dystonia.
  • Secondary dystonia, particularly in heredodegenerative and metabolic disorders, shows poor or variable outcomes with DBS.
  • Controlled studies are limited, especially for secondary dystonia, impacting clear efficacy determination.

Conclusions:

  • Bilateral internal globus pallidus stimulation is a safe and effective long-term treatment for hyperkinetic disorders.
  • Evidence supports DBS for primary dystonia, myoclonus-dystonia, and tardive dystonia.
  • Further controlled research is needed to refine DBS target selection for secondary dystonia.