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Related Concept Videos

Laminins are the Adhesive Proteins of Basal Lamina00:55

Laminins are the Adhesive Proteins of Basal Lamina

Laminins are heterotrimeric proteins with high molecular mass found in the extracellular matrix. Each laminin molecule is composed of three chains, viz. alpha, beta, and gamma, coded by five, four, and three paralogous genes, respectively. Laminins are categories based on the compositions of the three chains.
In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...
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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
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Related Experiment Video

Updated: May 16, 2026

Assessment and Characterization of Hyaloid Vessels in Mice
08:22

Assessment and Characterization of Hyaloid Vessels in Mice

Published on: May 15, 2019

Laminins and retinal vascular development.

Malia M Edwards1, Olivier Lefebvre

  • 1The Wilmer Eye Institute, Baltimore, MD, USA. medwar28@jhmi.edu

Cell Adhesion & Migration
|November 17, 2012
PubMed
Summary
This summary is machine-generated.

Understanding blood vessel formation is key for treating diseases like cancer and diabetic retinopathy. Laminins may play a crucial role in retinal vascular development, warranting further investigation for new therapies.

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Last Updated: May 16, 2026

Assessment and Characterization of Hyaloid Vessels in Mice
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Published on: May 15, 2019

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Retinal Explant of the Adult Mouse Retina as an Ex Vivo Model for Studying Retinal Neurovascular Diseases

Published on: December 9, 2022

Area of Science:

  • Vascular biology
  • Cell biology
  • Ophthalmology

Background:

  • Mechanisms of normal and pathological vascular development remain incompletely understood.
  • Abnormal blood vessel formation is implicated in diseases such as cancer and diabetic retinopathy.
  • Novel therapeutic targets are needed for vascular-related diseases.

Purpose of the Study:

  • To review recent studies on the role of laminin chains in retinal vascular development.
  • To highlight the importance of laminins in blood vessel formation in the retina.
  • To underscore the need for further research into laminins for potential therapeutic applications.

Main Methods:

  • Literature review of studies investigating laminins and retinal vascularization.
  • Analysis of research suggesting roles for laminin chains in blood vessel development.
  • Focus on the retina as a model system for vascular studies.

Main Results:

  • Recent studies indicate potential roles for laminin chains in retinal vascular development.
  • The retina serves as an accessible model for studying vascularization, particularly in rodents.
  • Laminins are emerging as significant factors in blood vessel formation.

Conclusions:

  • Further research into the involvement of laminins in retinal blood vessel formation is crucial.
  • Understanding laminin function may lead to novel therapeutic strategies for vascular diseases.
  • Laminins represent a promising area for advancing knowledge in vascular biology.