Endovascular brain intervention and mapping in a dog experimental model using magnetically-guided micro-catheter...

Area of Science:

• Neurology
• Biomedical Engineering
• Interventional Radiology

Background:

• Current endovascular techniques face limitations in accessing deep cerebral vasculature due to its complex and tortuous nature.
• Existing interventional devices offer restricted and complicated access, particularly to intra-cerebral vessels, hindering diagnosis and treatment of CNS disorders.

Purpose of the Study:

• To develop and evaluate a novel micro-catheter system guided by magnetic technology.
• The system is specifically designed for precise endovascular intervention and electrical mapping within deep central nervous system (CNS) vascular structures.

Main Methods:

• Utilized a novel, magnetically-guided micro-catheter system.
• Employed the NIOBE II system for magnetic guidance and control.
• Performed electrical brain activity mapping via the venous system in an animal dog model.

Main Results:

• The developed micro-catheter safely reached deep intra-cerebral venous structures.
• Successful mapping of electrical activity within these previously inaccessible deep brain regions was achieved.
• Demonstrated the feasibility of using the NIOBE II technology for navigation and intervention in the CNS.

Conclusions:

• This study presents the first successful application of a novel micro-catheter combined with NIOBE II technology for endovascular intervention in the brain.
• The technology enables safe and effective access to deep cerebral venous structures for diagnostic and potentially therapeutic purposes.
• This advancement holds promise for improving the diagnosis and treatment of various central nervous system (CNS) disorders.