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Repopulation of marrow after transplantation: MR imaging with pathologic correlation
S K Stevens1, S G Moore, M D Amylon
1Department of Diagnostic Radiology, Stanford University Medical Center, CA 94305-5105.
Radiology
|April 1, 1990
Summary
Magnetic resonance (MR) imaging reveals a distinct band pattern in vertebral marrow post-bone marrow transplant, aiding in assessing marrow regeneration and engraftment. This pattern helps differentiate normal marrow repopulation from residual or malignant disease.
Area of Science:
- Radiology
- Hematology
- Oncology
Background:
- Bone marrow transplantation (BMT) is a critical treatment for various hematologic and oncologic conditions.
- Assessing marrow regeneration and engraftment post-BMT is crucial for patient outcomes.
- Magnetic resonance (MR) imaging offers non-invasive insights into bone marrow composition.
Purpose of the Study:
- To characterize the MR appearance of vertebral marrow regeneration following BMT.
- To correlate MR findings with bone marrow biopsy and pathologic examination.
- To evaluate the utility of MR imaging in monitoring engraftment and detecting residual disease.
Main Methods:
- Sixty-seven lumbar spine MR studies were performed in 15 patients post-BMT.
- T1-weighted and short inversion time inversion recovery (STIR) sequences were utilized.
- MR findings were correlated with bone marrow biopsy and histopathology.
Main Results:
- A characteristic peripheral band of intermediate signal intensity and a central bright signal intensity zone were observed on T1-weighted MR images.
- Reciprocal changes were noted on STIR images.
- Histopathology confirmed the central zone as fatty marrow and the peripheral zone as regenerating hematopoietic cells.
Conclusions:
- The described MR band pattern represents normal marrow regeneration post-BMT.
- This imaging pattern can aid in screening for residual marrow disease.
- MR imaging is valuable for determining marrow engraftment and distinguishing normal from malignant cell repopulation.