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Osteosarcomatosis.

K D Hopper1, R P Moser, D B Haseman

  • 1Department of Radiology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.

Radiology
|April 1, 1990
PubMed
Summary
This summary is machine-generated.

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Osteosarcomatosis, characterized by multiple osteosarcoma sites, is often metastatic from a primary tumor. This condition is more common in mature skeletons than previously thought.

Area of Science:

  • Oncology
  • Radiology
  • Pathology

Background:

  • Osteosarcomatosis, defined as multiple skeletal sites of osteosarcoma, is a rare condition.
  • Previous understanding suggested a multifocal origin for this disease.

Purpose of the Study:

  • To investigate the origin and characteristics of osteosarcomatosis.
  • To differentiate between multifocal and metastatic origins of osteosarcomatosis.

Main Methods:

  • Retrospective review of 29 osteosarcomatosis cases from the Armed Forces Institute of Pathology radiographic files.
  • Analysis of demographic data, skeletal distribution, and radiographic appearance of lesions.
  • Comparison of lesion characteristics between patients under and over 18 years old.

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Main Results:

  • Osteosarcomatosis presented differently in younger (<18 years) versus older (>18 years) patients, with younger patients showing symmetric, rapidly appearing lesions and older patients exhibiting fewer, asymmetric lesions.
  • A dominant primary skeletal tumor was identified in 28 of 29 cases.
  • Pulmonary metastases were common and often detected concurrently with bone lesions.

Conclusions:

  • The findings support a metastatic origin from a primary dominant osteosarcoma as the likely basis for osteosarcomatosis.
  • Osteosarcomatosis is more frequently observed in mature skeletons than previously recognized.