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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
Evolution of Microbial Genome01:08

Evolution of Microbial Genome

Microbial genome evolution is a highly dynamic process shaped by continual gene gain and loss across species and strains. This genomic flexibility allows microorganisms to adapt rapidly to environmental pressures and interactions with other organisms. Central to understanding this diversity is the distinction between the core and pan genomes.The core genome comprises the genes shared by all sampled strains of a species, representing essential functions needed for fundamental cellular processes.
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

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An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

The UCSC Genome Browser database: extensions and updates 2013.

Laurence R Meyer1, Ann S Zweig, Angie S Hinrichs

  • 1Center for Biomolecular Science and Engineering, School of Engineering, University of California Santa Cruz (UCSC), Santa Cruz, CA 95064, USA.

Nucleic Acids Research
|November 17, 2012
PubMed
Summary
This summary is machine-generated.

The University of California Santa Cruz (UCSC) Genome Browser provides public access to genomic data for 63 organisms. Recent updates include new genome assemblies and improved usability features for researchers.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Computational Biology

Background:

  • The UCSC Genome Browser is a vital online resource for accessing and analyzing genomic data.
  • It hosts a comprehensive database of genomic sequences and annotations for numerous species.

Purpose of the Study:

  • To provide an update on the UCSC Genome Browser's database and features.
  • To highlight recent additions and improvements in genomic data accessibility and analysis.

Main Methods:

  • The UCSC Genome Browser integrates genomic sequences and annotation tracks.
  • Data is visualized, compared, analyzed, and shared through an online platform.
  • New genome assemblies and annotation tracks are regularly added and updated.

Main Results:

  • As of September 2012, data for 63 organisms is available, with ongoing expansion.
  • 19 new genome assemblies were added in the past year, with more planned.
  • Usability enhancements, including new navigation menus, have been implemented.

Conclusions:

  • The UCSC Genome Browser continues to expand its genomic data resources.
  • Regular updates and feature improvements enhance its utility for the scientific community.
  • It remains a key tool for genomic research and data sharing.